Recombinant adeno-associated viruses (rAAVs) have been effective tools for delivering gene therapy treatment and for manipulation of acquired diseases. Unfortunately, there is no effective method to target gene therapy for adipose tissue and transduction efficiency is low in naturally occuring AAV…

Obesity and the related condition, syndrome X (or metabolic syndrome) represent two of the most significant causes of morbidity in the western world and their incidences are growing rapidly. Lifestyle and non-pharmacologic approaches have limited efficacy, particularly in the morbidly obese. One s…