TS-039359 — Development of a strain that is useful for screening compounds that inhibit YidC in E. coli and identification of compounds with antibacterial activity.
In bacteria, the YidC membrane protein functions in the insertation of proteins into the cytoplasmic membrane of E. coli. This protein is essential for life and is evolutionarily conserved.
The rise of drug-resistant bacterial pathogens has created an urgent demand for novel antibiotic treatmen…
