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Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming "Shawn"; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"
Overcoming cancer drug resistance by targeted production of reactive oxygen species in mitochondria
TS-037308 — A nanoparticle capable of causing targeted reactive oxygen species damage to the energy-producing organelles that sustain plasma membrane efflux pump function, allowing for intracellular retention of anticancer drugs
Multidrug resistance, the ability of cancer cells to develop resistance to chemotherapy drugs, is a major cause of tumor recurrence and cancer metastasis. One of the primary contributors to cancer cells developing this resistance is overexpression of membrane transporter-based efflux pumps in a ce…
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming; Li, Xiaodong; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"

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