Available Technologies

# of Displayed Technologies: 7 / 7

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Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"
Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming "Shawn"; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"
Multifunctional RNA Nanoparticles and Methods for Treating Cancer
TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.
Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…
  • College: College of Pharmacy
  • Inventors: Zhang, Xiaoting; Guo, Peixuan
  • Licensing Officer: Flammang, Ann Marie
Synthetic apratoxins and novel analogs for anticancer and therapeutic applications
TS-039269 — Synthetic natural apratoxins and non-natural apratoxin analogs with improved pharmacokinetic profiles for cancer treatments and drug development applications.
Apratoxins are potent cytotoxic biosynthetic products that are naturally produced by specific marine microorganisms. When isolated from organisms, the compounds display very potent anticancer activities. In addition, they have been implicated in immunosuppressive activity. However, in their natura…
  • College: College of Arts & Sciences
  • Inventors: Forsyth, Craig; Jackel, Matthew; Li, Xiao
  • Licensing Officer: Ezzell, Janel
Electrolyte to Enable Reversible Dendrite-Free Potassium Plating and Stripping for Potassium Secondary Batteries
TS-037854 — A novel electrolyte to prevent dendrite growth in potassium air batteries.
The Need Potassium-air batteries have recently emerged as alternative energy storage devices beyond lithium-ion batteries. However, potassium metal anodes suffer from poor reversibility during plating and stripping processes due to their high reactivity and unstable solid electrolyte interphase (SE…
  • College: College of Arts & Sciences
  • Inventors: Wu, Yiying; McCulloch, William; Xiao, Neng
  • Licensing Officer: Bartell, Cordellia
Overcoming cancer drug resistance by targeted production of reactive oxygen species in mitochondria
TS-037308 — A nanoparticle capable of causing targeted reactive oxygen species damage to the energy-producing organelles that sustain plasma membrane efflux pump function, allowing for intracellular retention of anticancer drugs
Multidrug resistance, the ability of cancer cells to develop resistance to chemotherapy drugs, is a major cause of tumor recurrence and cancer metastasis. One of the primary contributors to cancer cells developing this resistance is overexpression of membrane transporter-based efflux pumps in a ce…
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming; Li, Xiaodong; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"
Collapsible Anvil for Circular Surgical Stapler
TS-014834 — An improved device for surgical end-to-end anastomosis, a procedure common in Roux-en-Y gastric bypass
Roux-en-Y laparoscopic gastric bypass is regarded as the ‘gold-standard-of-care’ for morbidly obese patients, classified as individuals with a body mass index (BMI) > 40. During the procedure, the surgeon creates a small hole, called an anastomosis, to reconnect the newly created st…
  • College: College of Engineering (COE)
  • Inventors: Nelson, Mark; Hoffman, Joshua; Hogrebe, Nathaniel; Liu, Xiaoli; Scheitlin, Christopher
  • Licensing Officer: Dahlman, Jason "Jay"

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