TS-037308 — A nanoparticle capable of causing targeted reactive oxygen species damage to the energy-producing organelles that sustain plasma membrane efflux pump function, allowing for intracellular retention of anticancer drugs
Multidrug resistance, the ability of cancer cells to develop resistance to chemotherapy drugs, is a major cause of tumor recurrence and cancer metastasis. One of the primary contributors to cancer cells developing this resistance is overexpression of membrane transporter-based efflux pumps in a ce…
