Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and the current therapies are not curative. High-risk genetic modifications are associated with poor response to traditional therapies. Flavopiridol, a broad-spectrum cyclin-dependent kinase inhibitor, activates significant clini…

Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocyti…

Molecular changes due to malignant tumors and toxicity of chemotherapeutic regimen suppress the immune system of cancer patients. This immunosuppression also leaves patients vulnerable to opportunistic infections and reactivation of latent viral or mycobacterial infections. Immunostimulation, or a…