Available Technologies

# of Displayed Technologies: 10 / 14

Categories

Compact Cas9-based transcriptional regulators for in vivo gene regulation
TS-045681 — Cas9-derived constructs can be used to modulate gene expression, but physical limitations restrict the application of this technique. Researchers at The Ohio State University have overcome this obstacle by engineering new Cas9-derived transcription factors.
CRISPR/Cas9 systems have revolutionized the field of programmable DNA technology. Recently, a version of the Cas9 protein with a deactivated nuclease domain called “dCas9” was developed. Without this domain, dCas9’s range of activity is limited to recognizing and binding sequence…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Dahlman, Jason "Jay"
Multifunctional RNA Nanoparticles and Methods for Treating Cancer
TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.
Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…
  • College: College of Pharmacy
  • Inventors: Zhang, Xiaoting; Guo, Peixuan
  • Licensing Officer: Flammang, Ann Marie
RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing
TS-039514 — Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.
New rapid and accurate sequencing methods, and disease detection methods are always in high demand. Newer advances in these areas include membrane-anchored structures and synthetics, which allow molecule idenfication and biopolymer sequencing by measuring conductance changes associated with passag…
  • College: College of Pharmacy
  • Inventors: Guo, Peixuan; Li, Hui; Wang, Shaoying
  • Licensing Officer: Flammang, Ann Marie
Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"
Al-Cr-Ti-V Based High Entropy Alloys
TS-037543 — Innovative alloys displaying extremely high strength and improving upon other mechanical properties
High entropy alloys (HEA) are a new class of multiple-principle-element alloys stabilized by large configurational entropy. HEA offer exceptional mechanical, chemical, and magnetic properties at room and elevated temperatures. Current efforts in the HEA field have focused on developing new materia…
  • College: College of Engineering (COE)
  • Inventors: Luo, Aihua "Alan"; Huang, Xuejun; Sun, Weihua
  • Licensing Officer: Bartell, Cordellia
A Wearable Integrated System of Augmented Reality for Targeted Pathologic Specimen Sampling
TS-037535 — An integrated system to improve the quality of analysis of the resected tumor specimen that provides the pathologist with the latest technological and scientific advancements.
In the field of cancer pathology, the identification and sampling of tumors is essential for both surgical applications and treatment plans for patients that may include post-operative chemotherapy and/or radiation therapy. Currently pathologists and pathologist assistants rely on visual and tacti…
  • College: College of Engineering (COE)
  • Inventors: Yilmaz, Alper; Hall, Nathan; Hitchcock, Charles; Lee, Young Jin; Martin, Edward; Nichols, Shawnn; Ozer, Enver; Povoski, Stephen; Sachire, Jennifer; Xu, Ronald
  • Licensing Officer: Norris, Francis "Frank"
Novel bacterial Type II topoisomerase inhibitors for the treatment of bacterial infections
TS-037293 — Bacterial infections such as sexually transmitted diseases, meningitis, pneumonia, tuberculosis (TB), and tetanus are some of the most common infectious diseases. However, there are few drugs that can be used against all of these diseases, and several bacteria have developed resistance to many com…
  • College: College of Pharmacy
  • Inventors: Mitton-Fry, Mark
  • Licensing Officer: Flammang, Ann Marie
Variable stiffness robotic arm via layer jamming
TS-036965 — A novel design for a robotic arm that mitigates injury risk due to human-robot collisions and does not sacrifice performance, which allows better integration of robotics into the workforce.
Robotics have evolved to perform many tasks in healthcare, automobile manufacturing, consumer product manufacturing, and defense applications. As the integration of robotics into the workforce increases, many industries seek human-safe designs (1) that optimize the performance of the robot and (2)…
  • College: College of Engineering (COE)
  • Inventors: Su, Haijun; Hurd, Carter; Pei, Xu
  • Licensing Officer: Zinn, Ryan
Bioluminescent Clavibacter Michiganensis
TS-015169 — Bioluminescent Clavibacter michiganensis subspecies michiganensis (Cmm) strains are used as a tool for monitoring and developing disease control products for tomatoes
Currently, there are no tomato varieties that are resistant to Clavibacter michiganensis subspecies michiganensis (Cmm). Furthermore, Cmm-plant interactions are poorly understood. Developing an understanding of Cmm strains will allow growers to develop products that are highly active against this …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Miller, Sally; Rajashekara, Gireesh; Xu, Xiulan
  • Licensing Officer: Dahlman, Jason "Jay"
Power Over Fiber Based Gate Drive Circuit
TS-015120 — The introduced power over fiber based gate drive circuit can be used drive semiconductor devices in a wide range of applications.
Recently, interest in high-voltage (HV) Silicon Carbide (SiC) based semiconductor power devices and their applications has grown. Many HV SiC based semiconductor power devices have been developed to date. The gate drive circuit of HV SiC power devices is critical to ensure fast and reliable switch…
  • College: College of Engineering (COE)
  • Inventors: Wang, Jin; Li, He; Zhang, Xuan
  • Licensing Officer: Hong, Dongsung

Show More Technologies

Loading icon